The City of Syracuse Department of Neighborhood and Business Development administers the federal Community Development Block Grant (CDBG), Emergency Shelter Grant (ESG), and HOME Investment Partnership Grant for the City of Syracuse. Serving as a catalyst for development in the City's neighborhoods, this program distributes grants for a wide range of projects which address the housing, economic, and human service needs of low and moderate income residents and neighborhoods.

The Department of Neighborhood and Business Development's vision is to provide all residents with vibrant neighborhoods that contain good housing choices, prosperous businesses, and abundant recreational opportunities. The focus of the Department is on developing and maintaining healthy neighborhoods, and investing in community and economic development in order to illustrate Syracuse's marketability. The Department of Neighborhood and Business Development works with many agencies and operates several programs to accomplish this goal.